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Generic Name: Metformin hydrochloride, dosage Form: tablet, film coated, medically reviewed on January 1, 2018, show On This Page. View All, metformin Description, metformin hydrochloride tablets, USP are metformin for cholesterol oral antihyperglycemic drugs used in the management of type 2 diabetes. Metformin hydrochloride diamide hydrochloride) is not chemically or pharmacologically related to any other classes metformin for cholesterol of oral antihyperglycemic agents. The structural formula is as shown: Metformin hydrochloride USP is a white to off-white crystalline compound with a molecular formula of C4H11N5 HCl and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of Metformin.4. The pH of a 1 aqueous solution of Metformin hydrochloride.68. Metformin hydrochloride tablets, USP contain 500 mg, 850 mg, or 1,000 mg of Metformin hydrochloride USP. Each tablet contains the inactive ingredients povidone, microcrystalline cellulose, sodium starch glycolate and magnesium stearate. In addition, the coating for the tablets contains hypromellose and polyethylene glycol. Metformin - Clinical Pharmacology, mechanism of Action. Metformin is an antihyperglycemic agent which metformin for cholesterol improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Its pharmacologic mechanisms of action are different from other classes of oral antihyperglycemic agents. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Unlike sulfonylureas, Metformin does metformin for cholesterol not produce hypoglycemia in either patients with type 2 diabetes or normal subjects (except in special circumstances, see. Precautions ) and does not cause hyperinsulinemia. With Metformin therapy, insulin secretion remains unchanged while fasting insulin levels and day-long plasma insulin response may actually decrease. Pharmacokinetics, absorption and Bioavailability, the absolute bioavailability of a Metformin hydrochloride 500 mg tablet given under fasting conditions is approximately 50. Studies using single oral doses of Metformin hydrochloride tablets 500 mg to 1,500 mg, and 850 mg to 2,550 mg, indicate that there is a lack of dose proportionality with increasing doses, which is due to decreased absorption rather than an alteration in elimination. Food decreases the extent of and slightly delays the absorption of Metformin, metformin for cholesterol as shown by approximately a 40 lower mean peak plasma concentration (Cmax a 25 lower area under the plasma concentration versus time curve (AUC and a 35-minute prolongation of time to peak plasma. The clinical relevance of these decreases is unknown. Distribution, the apparent volume of distribution (V/F) of Metformin following single oral doses of Metformin hydrochloride tablets 850 mg averaged. Metformin is negligibly bound to plasma proteins, in contrast to sulfonylureas, which are more than 90 protein bound. Metformin partitions into erythrocytes, most likely as a function of time. At usual clinical doses and dosing schedules of Metformin hydrochloride tablets, steady state plasma concentrations of Metformin are reached within 24 to 48 hours and are generally 1 g/mL. During controlled clinical trials of Metformin hydrochloride tablets, maximum Metformin plasma levels did not exceed 5 g/mL, even at maximum doses. Metabolism and Elimination, intravenous single-dose studies in normal subjects demonstrate that Metformin is excreted unchanged in the urine and does not undergo hepatic metabolism (no metabolites have been identified in humans) nor biliary excretion. Renal clearance (see Table 1) is approximately.5 times greater than creatinine clearance, which indicates that tubular secretion is the major route of Metformin elimination. Following oral administration, approximately 90 of the absorbed drug is eliminated via the renal route within the first 24 hours, with a plasma elimination half-life of approximately.2 hours.
Generic Name: metformin (met FOR min brand Names: Fortamet, Glucophage, Glucophage XR, Glumetza, Riomet. Medically reviewed on November 9, 2017. Metformin is an oral diabetes medicine metformin b12 that helps control blood sugar levels. Metformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Metformin is sometimes used together with insulin or other medications, but it is not for treating type 1 diabetes. Important information, you should not use metformin if you have severe kidney disease or diabetic ketoacidosis (call your doctor for treatment). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking metformin. This medicine may cause a serious condition called lactic acidosis. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. Metformin side effects, get emergency medical help if you have signs of an allergic reaction to metformin: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Some people develop lactic acidosis while metformin b12 taking this metformin b12 medicine. Early symptoms may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness; numb or cold feeling in your arms and legs; trouble breathing; feeling dizzy, light-headed, tired, or very weak; stomach pain, nausea with vomiting; or slow or uneven heart rate. Common metformin side effects may include: low blood sugar; nausea, upset stomach; or diarrhea. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. See also: Side effects (in more detail before taking this medicine. You should not use metformin if you are allergic to it, or if you have: severe kidney disease; or metabolic or diabetic ketoacidosis (call your doctor for treatment). To make sure this medicine is safe for you, tell your doctor if you have ever had: kidney disease (your kidney function may need to be checked before you take this medicine high ketone levels in your blood or urine; heart disease, congestive heart failure;. Some people taking metformin develop a serious condition called lactic acidosis. This may be more likely if you have liver or kidney disease, congestive heart failure, surgery, a heart attack or stroke, a severe infection, if you are 65 or older, if you are dehydrated, or if you drink a lot of alcohol. Talk with your doctor about your risk. Follow your doctor's instructions about using this medicine if you are pregnant. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester of pregnancy. Tell your doctor if you become pregnant while taking metformin. It is not known whether metformin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. Metformin should not be given to a child younger than 10 years old. Some forms of metformin are not approved for use by anyone younger than 18 years old. How should I take metformin? Take metformin exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended. Take metformin with a meal, unless your doctor tells you otherwise. Some brands of this medicine are taken metformin b12 only once daily with the evening meal. Follow your doctor's instructions. Do not crush, chew, or break an extended-release tablet. Swallow the tablet whole. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup.
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