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For other uses, see. Sildenafil, sold as mixing viagra and cialis the brand name. Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. 3, its effectiveness for treating sexual dysfunction in women has not been demonstrated. 3, common side effects include headaches and heartburn, as well as flushed skin. Caution is advised in those who have cardiovascular disease. Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss. Sildenafil should not be taken by people who take nitrates such as nitroglycerin (glycerin trinitrate as this mixing viagra and cialis may result in a severe mixing viagra and cialis and potentially fatal drop in blood pressure. 3, sildenafil acts by inhibiting cGMP-specific phosphodiesterase type 5 (phosphodiesterase 5, PDE5 an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis. Pfizer scientists, andrew Bell, David Brown, and Nicholas Terrett originally discovered sildenafil as a treatment for various cardiovascular disorders. 4 5, since becoming available in 1998, sildenafil has been a common treatment for erectile dysfunction; its primary competitors are tadalafil (trade name Cialis) and vardenafil (Levitra). Contents Medical uses 50mg tablets of sildenafil Sexual dysfunction The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. 6 Antidepressant-associated sexual dysfunction Tentative evidence suggests that sildenafil may help men who experience antidepressant -induced erectile dysfunction. 7 Pulmonary hypertension While sildenafil improves some markers of disease in people with pulmonary arterial hypertension, it does not appear to affect the risk of death or serious side effects as of 2014. 8 Raynaud's phenomenon Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon ; 9 10 these drugs have moderate efficacy for reducing the frequency and duration. 9 As of 2016, their role more generally in Raynaud's was not clear. 10 Adverse effects In clinical trials, the most common adverse effects of sildenafil use included headache, flushing, indigestion, nasal congestion, and impaired vision, including photophobia and blurred vision. 2 Some sildenafil users have complained of seeing everything tinted blue mixing viagra and cialis ( cyanopsia ). 11 Some complained of blurriness and loss of peripheral vision. In July 2005, the FDA found that sildenafil could lead to vision impairment in rare cases 12 and a number of studies have linked sildenafil use with non-arteritic anterior ischemic optic neuropathy. 13 Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. 2 In October 2007, the FDA announced that the labeling for all PDE5 inhibitors, including sildenafil, required a more prominent warning of the potential risk of sudden hearing loss. 14 Interactions Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. 2 Other drugs that interfere with the metabolism of sildenafil include erythromycin and cimetidine, both of which can also lead to prolonged plasma half-life levels. The use of sildenafil and an 1 blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy ) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least. 15 Contraindications Contraindications include: 2 :11 Concomitant use of nitric oxide donors, organic nitrites and nitrates, 16 such as: Concomitant use of soluble guanylyl cyclase stimulators, such as riociguat Known hypersensitivity to sildenafil Sildenafil should not be used if sexual activity is inadvisable due. Citation needed Nonmedical use Recreational use Sildenafil's popularity with young adults has increased over the years.
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Is there a generic cialis available
Because of stinging is there a generic cialis available nettles antihistamine and anti-inflammatory qualities, it can be a natural treatment for eczema, as the is there a generic cialis available Penn State University College of Medicine study referenced above notes. Eczema Eczema is a dry, itchy rash that can last on sufferers for a very long time. Because prolonged use is there a generic cialis available of nsaids can cause a number of serious side effects, this is an ideal pairing. Stinging nettle products come in dried or freeze-dried leaf form, extract, capsules, tablets, as well as a root tincture (suspension of the herb in alcohol juice or tea. Its also used in home remedies for bladder is there a generic cialis available infections. Nettle Tea Stinging nettle leaves and flowers can be dried, and the dried leaves can be steeped and made into a tea. When taken orally, nettle helps provide relief. Sufferers can use a combination of nettle taken orally to tackle the eczema internally, as well as a cream to provide relief from the rashs itch and redness. BPH sufferers experience varying levels of increased urges to urinate, incomplete emptying is there a generic cialis available of the bladder, painful urination, post urination dripping and reduced urinary flow. Its best to use young leaves. A testosterone-induced BPH study on rats has shown that stinging nettle may be as effective at treating this condition as finasteride, the medication commonly used to treat BPH. There are many variations of nettle tea recipes that feature a number of other herbs like raspberry leaf, echinacea or goldenseal. Nettle works alongside nonsteroidal anti-inflammatory drugs (nsaids) to allow patients to decrease their nsaid use. BPH symptoms are caused by an enlarged prostate gland pressing on the urethra. Journal of Rheumatology shows stinging nettles anti-inflammatory power against other autoimmune diseases like rheumatoid arthritis. Another study published in the. Bleeding Certain products containing stinging nettle have shown that, when applied to the skin, it can reduce bleeding during surgery. Studies also show that applying nettle leaf topically at the site of pain decreases joint pain and can treat arthritis. Benign Prostatic Hyperplasia (BPH) and Urinary Issues. Stinging nettles anti-inflammatory qualities affect a number of key receptors and enzymes in allergic reactions, preventing hay fever symptoms if taken when they first appear. According to the University of Maryland Medical Center, the plant has been used most commonly throughout history as a diuretic and for treating painful muscles and joints, eczema, arthritis, gout, and anemia. Another global study from the National College of Naturopathic Medicine found that stinging nettle use for allergy relief was rated higher than placebos in a 98-person, randomized, double-blind study. ( 8 ) There is also evidence that in severe reactions, low plasma histamine levels (as opposed to high levels) are present. Allergies cause uncomfortable congestion, sneezing, itching and more. Some of the more common stinging nettle uses include:. Before purchasing or making a stinging nettle product, its important to identify whether your ailment needs the aboveground parts or the roots, as they have different pharmacological qualities. Osteoarthritis and Joint Pain, arthritis sufferers often experience joint pain, typically in the hands, knees, hips and spine. ( 7 ) The leaves of the plant contain histamine, which may seem counterproductive in allergy treatment, but there is history of using histamines to treat severe allergic reactions. Studies have shown it has antioxidant, antimicrobial, anti-ulcer, astringent and analgesic capabilities. The leaves can be steamed and cooked much like spinach.
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